XP Screens – Intelligent Crystal Screens-MiTeGen智能晶体筛选屏幕
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XP Screens – Intelligent Crystal Screens
XP Screens promote protein crystallization even for most challenging targets and improve diffraction quality of protein crystals. The XP Screens are TEW-optimized JBScreen Basics: 96 of the most prominent crystallization conditions complemented with TEW as “glue” for protein molecules.
XP 屏幕 – 智能水晶屏幕
即使对于最具挑战性的目标，XP Screens 也能促进蛋白质结晶，并提高蛋白质晶体的衍射质量。 XP Screens 是 TEW 优化的 JBScreen 基础：96 种最突出的结晶条件与 TEW 作为蛋白质分子的“胶水”相辅相成。
There are two variations of the XP Screens:
The XP Screen, SKU M-CS-350, is a convenient initial screen that has successfully induced protein crystallization with low TEW concentrations such as 1 mM. In some cases however, higher concentration of 5 or 10 mM TEW are needed.
The XP Up Screen, SKU M-CS-351, is an upgrade of the well-established XP Screen. It contains 96 of the most prominent screening solutions that are long-term stable in the presence of up to 10 mM TEW.
The Anderson-Evans Polyoxotungstate (TEW), SKU M-X-TEW-5, is a universal and flexible crystallization additive that is integrated the XP Screens. It was shown to improve crystal quality and resolution.
XP 屏幕有两种变体：
XP Screen，SKU M-CS-350，是一种方便的初始筛选，已成功诱导低 TEW 浓度（如 1 mM）的蛋白质结晶。 然而，在某些情况下，需要更高浓度的 5 或 10 mM TEW。
XP Up Screen SKU M-CS-351 是成熟的 XP Screen 的升级版。 它包含 96 种最突出的筛选解决方案，在高达 10 mM TEW 的情况下长期稳定。
Anderson-Evans 聚氧钨酸盐 (TEW)，SKU M-X-TEW-5，是一种通用且灵活的结晶添加剂，与 XP Screens 集成。 它被证明可以提高晶体质量和分辨率。
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- Tech Notes
The Advantages of XP Screens include:
- Convenient initial screening with up to 10 mM TEW
- Improved crystal quality and resolution
- Tight crystal contacts
- New crystal forms (e.g to provide access to binding pockets)
- Direct phasing
The Anderson-Evans Polyoxotungstate [TeW6 O24] 6- (TEW), SKU M-X-TEW-5, is a universal and flexible crystallization additive that is integrated in the XP Screens. It was shown to improve crystal quality and resolution by:
- Binding to the protein surface and forming tight crystal lattice contacts[3-7]
- Acting as linker in various orientations and thereby creating either smaller
(PDB: 4OUA) or larger (PDB: 4PHI) protein-protein distances[3,4] - Heterogeneous crystallization of two different protein forms in one single crystal
(PDB: 4OUA)[4] - Inducing new crystal forms with access to the active site (PDB: 6ZDK, 6ZDL, 6ZFA)[5]
- Covalently binding and structurally adapting to fit into protein molecules
(PDB: 4Z12, 4Z13)[2]
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技术说明
XP Screens 的优点包括：使用高达 10 mM TEW 进行便捷的初始筛选
提高晶体质量和分辨率
紧密的水晶触点
新的晶体形式（例如提供对结合口袋的访问）
直接定相
Anderson-Evans 聚氧钨酸盐 [TeW6 O24] 6- (TEW)，SKU M-X-TEW-5，是一种通用且灵活的结晶添加剂，可集成到 XP Screens 中。它被证明可以通过以下方式提高晶体质量和分辨率：与蛋白质表面结合并形成紧密的晶格接触[3-7]
充当各种方向的链接器，从而创建更小的
（PDB：4OUA）或更大（PDB：4PHI）蛋白质-蛋白质距离[3,4]
一种单晶中两种不同蛋白质形式的异质结晶
（PDB：4OUA）[4]
通过访问活性位点诱导新的晶体形式（PDB：6ZDK、6ZDL、6ZFA）[5]
共价结合并在结构上适应以适应蛋白质分子
(PDB: 4Z12, 4Z13)[2]