Corning TransportoCells HEK293-derived ABC transporter vesicles express more human-like transporter proteins within the human cellular membrane. These HEK membrane vesicles have demonstrated a significantly higher uptake activity and lower background as compared with traditional insect cell-derived vesicles. The validated vesicle model could potentially improve in vitro to in vivo prediction because of the more in vivo-like recombinant proteins and membrane composition. The products can be used for drug transporter phenotyping, drug-drug interaction and toxicity studies, drug clearance prediction, and mechanistic studies of drug transport.

Contain more in vivo-like recombinant proteins and membrane composition, thus providing the potential for a better in vitro to in vivo correlation

Demonstrate a robust dynamic range with significantly higher uptake activity and lower background than insect cell expression systems

Has been fully validated for substrate specificity, transporter kinetics, and inhibition profiles

Support the USFDA, EMA, and ITC recommendations for the identification of drug transporters and transporter drug-drug interaction studies

Product Number

453801

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Species

Human

Protein Concentration

5 mg/mL

Transporter

MDR1/P-gp

Shelf Life

5 years

Storage

-80 C