The SWISSCI Hanging Drop Crystallisation Plug Plate is a novel system for protein crystallisation in a 96-well format. Individual wells can be identified, removed, and harvested using the supplied Allen key, eliminating the need for a scalpel and tape. The plate has been developed by SWISSCI together with leading Crystallographers. It is the result of many years of experience in successful robotic high-throughput crystallisation. The Plate offers unique properties that make it ideal for both nanolitre crystallisation screening and microliter optimisation alike. Made from optically superior polymer (UVP) and with a new design of the wells, the plate allows easy crystal viewing and retrieval.