The JBScreen Detergents contain 4x 24 unique detergents that are compatible with most common crystallization reagents and are therefore perfectly suited for membrane protein solubilization:

• Ionic detergents
• Non-ionic detergents
• Zwitterionic detergents
• Non-detergent Sulfobetaines
• Synthetic Lipids

The JBScreen Detergentscan be used throughout the protein purification process or can be added afterwards by dialysis or ion-exchange chromatography (detergent exchange). Detergent exchange can be vital for obtaining well-diffracting membrane-protein crystals [1].

JBScreen Detergents are also valuable for additive screening with detergents and detergent mixtures [2,3] in combination with the JBScreen Membrane. This combination will enable you to screen a broad range of crystallization conditions, while concentrating on the most successful detergents – and therefore making crystallization screening of membrane proteins much more efficient and less time consuming.

类别：结晶优化, 膜蛋白晶体筛选, 膜蛋白结晶
产品信息
产品描述
产品规格
JBScreen 去污剂包含 4x 24 种独特的去污剂，可与最常见的结晶试剂兼容，因此非常适合膜蛋白溶解：
离子洗涤剂
非离子洗涤剂
两性离子洗涤剂
非洗涤剂磺基甜菜碱
合成脂质
JBScreen Detergent 可以在整个蛋白质纯化过程中使用，也可以在之后通过透析或离子交换层析（去垢剂交换）添加。去污剂交换对于获得衍射良好的膜蛋白晶体至关重要 [1]。

JBScreen 去污剂与 JBScreen 膜结合使用，也可用于对去污剂和去污剂混合物进行添加剂筛选 [2,3]。这种组合将使您能够筛选广泛的结晶条件，同时专注于最成功的去污剂——从而使膜蛋白的结晶筛选更加高效和耗时更少。

References:
[1] Rosenow et al. (2003) The influence of detergents and amphiphiles on the solubility of the light harvesting complex. Acta Cryst. D59:1422
[2] Adir (1999) Crystallization of the oxygen-evolving reaction centre of photosystem II in nine different detergent mixtures. Acta Cryst. D55:891
[3] Koronakis et al. (2000) Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405:914

Download technical sheet from below:JBScreen Detergents HTS JBScreen Detergents 1 JBScreen Detergents 2 JBScreen Detergents 3 JBScreen Detergents 4

For additional questions please call +1 607 266 877 or email [email protected]