Grid boxes form an essential part of the Cryo-EM workflow as they enable the transfer and storage of vitrified samples on standard EM grids in liquid nitrogen storage dewars. The SWISSCI Cryo EM Grid Box has been specially developed to improve on many features of current solutions. The SWISSCI Cryo EM Grid Box has been developed in close collaboration with the MRC Laboratory of Molecular Biology in Cambridge. The SWISSCI Cryo EM Grid Box is made from a special polymer formulation for zero static at cryogenic temperatures. The box has four diamond-shaped slot positions with identification numbers. No special tools are required since the lid is rotated with standard laboratory tweezers. The Cryo EM Grid Box is of standard size for all common Cryo-EM sample mounting and storage devices.